John F. Kalinich, PhD
Assistant Professor
Radiation Biology
4301 Jones Bridge Road
Bethesda MD 20814
Office: 301-295-9242
Fax: 301-295-1731
kalinich@afrri.usuhs.mil
Our laboratory investigates the health effects of embedded metal fragments, including those metals found in military munitions (e.g., depleted uranium, tungsten alloys) and radiological dispersal devices (e.g., strontium, cobalt, iridium). We are interested in the mechanistic pathways of cellular damage as a result of metal exposure and hope to use this information to develop improved treatment procedures. In addition, we are also investigating the use of urinary biomarkers as a rapid noninvasive screening method to assess radiation exposure and dose.
Recent publications
- 2012—Emond CA and Kalinich JF, Biokinetics of embedded surrogate radiological dispersal device material, Health Physics [in press].
- 2009—Kane MA, Kasper CE, Kalinich JF, Protocol for the assessment of potential health effects from embedded metal fragments. Mil Med. 174(3):265–269, 2009.
- 2009—Kane MA, Kasper CE, Kalinich JF, The use of established skeletal muscle cell lines to assess potential toxicity from embedded metal fragments. Toxicol In Vitro. 23(2):356–359, 2009.
- 2008—Kalinich JF, Vergara VB, and Emond CE, Urinary and serum metal levels as indicators of embedded tungsten alloy fragments. Military Medicine 173: 754–758, 2008.
- 2005—Kalinich JF, Tungsten alloy and cancer in rats: Link to childhood leukemia?, Environmental Health Perspectives 113: A802, 2005.
- 2005—Kalinich JF, Emond CA, Dalton TK, Mog SR, Coleman GD, Kordell JE, Miller AC, and McClain DE, Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environmental Health Perspectives 113: 729–734, 2005.
- 2002—Kalinich JF, Ramakrishnan N, Villa V, and McClain DE, Depleted uranium-uranyl chloride induces apoptosis in mouse J774 macrophages. Toxicology 179: 105–114, 2002.
- 2001—McClain DE, Benson KA, Dalton TK, Ejnik J, Emond CA, Hamilton MM, Hodge SJ, Kalinich JF, Landauer MR, Matthews CR, Miller AC, Pellmar TC, Stewart MD, Villa VO, and Xu J, Health effects of embedded depleted uranium. Military Medicine 167 (suppl 1): 117–119, 2001.
- 2001—Kalinich JF and McClain DE, Staining of intracellular deposits of uranium in cultured murine macrophages. Biotechnic & Histochemistry 76: 247–252, 2001.
- 2001—McClain DE, Benson KA, Dalton TK, Ejnik J, Emond CA, Hamilton MM, Hodge SJ, Kalinich JF, Landauer MR, Matthews CR, Miller AC, Pellmar TC, Stewart MD, Villa VO, and Xu J, Biological effects of embedded depleted uranium (DU): A summary of AFRRI DU research. Science of the Total Environment 76: 247–252, 2001.
- 2000—Kalinich JF, Ramakrishnan R, McClain DE, and Ramakrishnan N, 4-Hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic T- and B-cell lines. Free Radical Research 33: 349–358, 2000.
- 2000—Miller AC, Xu J, Stewart M, Emond C, Hodge S, Matthews C, Kalinich J, and McClain D, Potential health effects of the heavy metals, depleted uranium and tungsten, used in armor-piercing munitions: Comparison of neoplastic transformation, mutagenicity, genomic instability, and oncogenesis. Metal Ions 6: 209–211, 2000.
- 2000—Kalinich JF, Ramakrishnan N, and McClain DE, A procedure for the rapid detection of depleted uranium in metal shrapnel fragments. Military Medicine 165: 626–629, 2000.
Book chapters - 2011—Kalinich JF, Heavy metal-induced carcinogenicity: Depleted uranium and heavy-metal tungsten alloy. In Cellular Effects of Heavy Metals (Banfalvi G., ed.), Springer Scientific Publishing, 2011.
- 2007—Kalinich JF and McClain DE, Colorimetric determination of uranium. In: Depleted Uranium: Properties, Uses, and Health Consequences (Miller AC, ed.), CRC Press, Boca Raton, FL, pp. 75–83, 2007.
Department
Research
Faculty
Graduate Education
AFRRI
Contact
Christopher R. Lissner, PhD, M(ASCP)
CAPT, MSC, USN Ret.
Scientific Director
Armed Forces Radiobiology Research
Institute & Acting Chair, Department
of Radiation Biology, School of Medicine,
Uniformed Services University
of the Health Sciences
Building 42, 8901 Wisconsin Avenue
Bethesda, Maryland 20889-5603
lissner@afrri.usuhs.mil
Tel 301-295-4995
FAX 301-295-4967
The image below is that of an announcement that appeared in Radiation Research, the official journal of the Radiation Research Society, for the USU PhD Program in Radiation Biology. Click the image to go to the home page of Radiation Research.
