Publications
- 1. Chattopadhyay, G., Q. Chen, J. Colino, A. Lees, and C. M. Snapper. 2009. Intact bacteria inhibit the induction of humoral immune responses to bacterial-derived and heterologous soluble T cell-dependent antigens. J Immunol 182:2011-2019.
- 2. Chen, Q., J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper. 2008. A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. J Immunol 181:8258-8266.
- 3. Vasilevsky, S., J. Colino, R. Puliaev, D. H. Canaday, and C. M. Snapper. 2008. Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice. J Immunol 181:1787-1797.
- 4. Vasilevsky, S., G. Chattopadhyay, J. Colino, T. J. Yeh, Q. Chen, G. Sen, and C. M. Snapper. 2008. B and CD4(+) T-cell expression of TLR2 is critical for optimal induction of a T-cell-dependent humoral immune response to intact Streptococcus pneumoniae. Eur J Immunol 38:3316-3326.
- 5. Chattopadhyay, G., A. Q. Khan, G. Sen, J. Colino, W. Dubois, A. Rubtsov, R. M. Torres, M. Potter, and C. M. Snapper. 2007. Transgenic Expression of Bcl-xL or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae. J Immunol 179:7523-7534.
- 6. Thomas-Rudolph, D., T. W. Du Clos, C. M. Snapper, and C. Mold. 2007. C-Reactive Protein Enhances Immunity to Streptococcus pneumoniae by Targeting Uptake to Fc{gamma}R on Dendritic Cells. J Immunol 178:7283-7291.
- 7. Lee, K. S., C. A. Scanga, E. M. Bachelder, Q. Chen, and C. M. Snapper. 2007. TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae. Cell Immunol 245:103-110.
- 8. Colino, J., and C. M. Snapper. 2007. Dendritic cell-derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice. Infect Immun 75:220-230.
- 9. Snapper, C. M. 2006. Differential regulation of protein- and polysaccharide-specific Ig isotype production in vivo in response to intact Streptococcus pneumoniae. Curr Protein Pept Sci 7:295-305.
- 10. Chen, Q., G. Sen, and C. M. Snapper. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177:6044-6051.
- 11. Colino, J., and C. M. Snapper. 2006. Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J Immunol 177:3757-3762.
- 12. Sen, G., Q. Chen, and C. M. Snapper. 2006. Immunization of aged mice with a pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4+-T-cell priming to young adult levels. Infect Immun 74:2177-2186.
- 13. Khan, A. Q., G. Sen, S. Guo, O. N. Witte, and C. M. Snapper. 2006. Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses. Infect Immun 74:1419-1424.
- 14. Sen, G., A. Q. Khan, Q. Chen, and C. M. Snapper. 2005. In Vivo Humoral Immune Responses to Isolated Pneumococcal Polysaccharides Are Dependent on the Presence of Associated TLR Ligands. J Immunol 175:3084-3091.
- 15. Baudler, S., J. Baumgartl, B. Hampel, T. Buch, A. Waisman, C. M. Snapper, W. Krone, and J. C. Bruning. 2005. Insulin-like growth factor-1 controls type 2 T cell-independent B cell response. J Immunol 174:5516-5525.
- 16. Khan, A. Q., Q. Chen, Z. Q. Wu, J. C. Paton, and C. M. Snapper. 2005. Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2. Infect Immun 73:298-307.
- 17. Sen, G., M. Flora, G. Chattopadhyay, D. M. Klinman, A. Lees, J. J. Mond, and C. M. Snapper. 2004. The critical DNA flanking sequences of a CpG oligodeoxynucleotide, but not the 6 base CpG motif, can be replaced with RNA without quantitative or qualitative changes in Toll-like receptor 9-mediated activity. Cell Immunol 232:64-74.
- 18. Khan, A. Q., A. Lees, and C. M. Snapper. 2004. Differential regulation of IgG anti-capsular polysaccharide and antiprotein responses to intact Streptococcus pneumoniae in the presence of cognate CD4+ T cell help. J Immunol 172:532-539.
- 19. Colino, J., and C. M. Snapper. 2003. Dendritic cells, new tools for vaccination. Microbes Infect 5:311-319.
- 20. Colino, J., and C. M. Snapper. 2003. Opposing signals from pathogen-associated molecular patterns and IL-10 are critical for optimal dendritic cell induction of in vivo humoral immunity to Streptococcus pneumoniae. J Immunol 171:3508-3519.
- 21. Colino, J., and C. M. Snapper. 2003. Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J Immunol 171:2354-2365.
- 22. Wu, Z. Q., A. Q. Khan, Y. Shen, K. M. Wolcott, W. Dawicki, T. H. Watts, R. S. Mittler, and C. M. Snapper. 2003. 4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae. Infect Immun 71:196-204.
- 23. Wu, Z. Q., Y. Shen, A. Q. Khan, C. L. Chu, R. Riese, H. A. Chapman, O. Kanagawa, and C. M. Snapper. 2002. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J Immunol 168:5551-5557.
- 24. Colino, J., Y. Shen, and C. M. Snapper. 2002. Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms. J Exp Med 195:1-13.
- 25. Khan, A. Q., Y. Shen, Z. Q. Wu, T. A. Wynn, and C. M. Snapper. 2002. Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect Immun 70:749-761.
- 26. Snapper, C. M., Y. Shen, A. Q. Khan, J. Colino, P. Zelazowski, J. J. Mond, W. C. Gause, and Z. Q. Wu. 2001. Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae. Trends Immunol 22:308-311.
- 27. Wu, Z. Q., A. Q. Khan, Y. Shen, J. Schartman, R. Peach, A. Lees, J. J. Mond, W. C. Gause, and C. M. Snapper. 2000. B7 requirements for primary and secondary protein- and polysaccharide- specific Ig isotype responses to Streptococcus pneumoniae. J Immunol 165:6840-6848.