USU Department of Microbiology
and Immunology

Johnan A. R. Kaleeba, Ph.D.

Assistant Professor

USUHS, Department of Microbiology and Immunology

Ph.D., Vaccine and Gene Therapy Institute of the Oregon Health Sciences University

jkaleeba@usuhs.mil

Research:  Tumor Markers and Molecular Signatures of Viral Oncogenesis

The research in our lab is focused on the basic biology of virus infection, identification of novel receptors and integrating virus-induced signaling events with post-entry events leading to establishment of a persistent state. My interest in cancer epidemiology involves understanding disease pathogenesis based on expression of specific disease markers in distinct populations as a basis for targeted vaccine development.
 

Kaleeba JA, Berger EA.  Broad target cell selectivity of Kaposi's sarcoma-associated herpesvirus glycoprotein-mediated cell fusion and virion entry.  Virology. 2006; 354(1):7-14.

Kaleeba JA, Berger EA.  Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.
Science. 2006;311(5769):1921-4.

Vandenbark AA, Barnes D, Finn T, Bourdette DN, Whitham R, Robey I, Kaleeba J, Bebo BF Jr, Miller SD, Offner H, Chou YK.  Differential susceptibility of human T(h)1 versus T(h) 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells.  Int Immunol. 2000;12(1):57-66.

Kaleeba JA, Bergquam EP, Wong SW.  A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.  J Virol. 1999;73(7):6177-81.

Kaleeba JA, Offner H, Vandenbark AA, Lublinski A, Weinberg AD. The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells.  Int Immunol. 1998;10(4):453-61.

Chou YK, Weinberg AD, Buenafe A, Bourdette DN, Whitham R, Kaleeba JA, Robey IF, Kavanagh DG, Offner H, Vandenbark AA.  MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells.  J Neurosci Res. 1996;45(6):838-51.

Ruben LN, Goodman AR, Johnson RO, Kaleeba JA, Clothier RH.  The development of peripheral TNP-tolerance and suppressor function in Xenopus laevis, the South African clawed toad.  Dev Comp Immunol. 1995;19(5):405-15.

Last updated: 05/25/07

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