Merrell Laboratory
 

Jeong-Heon Cha, Ph.D.

Visiting Scientist

USUHS, Department of Microbiology and Immunology

 Jeongheon.Cha.CTR @ usuhs.mil

Education

• 1984–1988 - B.S., College of Life & Environmental Sciences, Korea University, Seoul, Korea

• 1989–1991 M.A., Biology Department, Ball State University, Muncie, IN

• 1991-1996 - Ph.D., Biomedical Science, Department of Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, SC
   

Academic Positions

• 1996-2000 - Post-Doctoral Research Fellow in Dr. Leon Eidels’ laboratory, Department of Microbiology, UT Southwestern Medical Center, Dallas, TX

• 2000-2002 - Research-Track Instructor/Department of Microbiology,
  UT Southwestern Medical Center, Dallas, TX

• 2002-2003 - Research-Track Instructor/Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

• 2003-2004 - Research Assistant Professor/Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

• 2004-2007 - Assistant Professor/Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

• 2008-Present - Associate Professor/Department of Oral Biology,
  Yonsei University College of Dentistry, Seoul, Korea
   

Selected Publications

1. Cha, J.-H. and G.C. Stewart. The divIVA minicell locus of Bacillus subtilis. J. Bacteriol. 179:1671-1683 (1997).

2. Cha, J.-H., Hooper, K.P., and Eidels, L. Characterization of the Toxin-Binding Region of the Diphtheria Toxin Receptor/HB-EGF Precursor. In: Bacterial Protein Toxins, Eighth European Workshop, Kloster Banz, June 29 – July 4, 1997, p. 68-69 (Hacker, J., et al., eds.). Gustav Fischer Verlag, Stuttgart, Jena, New York (1998).

3. Brooke, J.S., Cha, J.-H., and Eidels, L. Diphtheria Toxin:Receptor Interaction. Association, Dissociation, and Effect of pH. Biochem. Biophys. Res. Commun. 248: 297-302 (1998).

4. Cha, J.-H., Brooke, J.S., and Eidels, L. Toxin Binding Site of the Diphtheria Toxin Receptor: Loss and Gain of Diphtheria Toxin Binding of Monkey and Mouse Heparin-Binding Epidermal Growth Factor-Like Growth Factor Precursors by Reciprocal Site-Directed Mutagenesis. Mol. Microbiol. 29: 1275-1284 (1998).
 

5. Cha, J.-H., Brooke, J.S., and Eidels, L. Hamster Diphtheria Toxin Receptor: a Naturally occurring Chimera of Monkey and Mouse HB-EGF precursors. Biochem. Biophys. Res. Commun. 254: 325-329 (1999).
 

6. Cha, J.-H., Brooke, J.S., Ivey, K. N., and Eidels, L. Cell-Surface Monkey CD9 Antigen is a Coreceptor that Increases Diphtheria Toxin Sensitivity and Diphtheria Toxin Receptor Affinity. In: Bacterial Protein Toxins, Ninth European Workshop, Ste. Maxime, June 27 – July 4, 1999, p. A28 (Locht, C., et al., eds.). Gustav Fischer Verlag, Stuttgart, Jena, New York (2000).
 

7. Cha, J.-H., Brooke, J.S., Ivey, K. N., and Eidels, L. Cell-Surface Monkey CD9 Antigen is a Coreceptor that Increases Diphtheria Toxin Sensitivity and Diphtheria Toxin Receptor Affinity. J. Biol. Chem. 275: 6901-6907 (2000).
 

8. Brooke J.S. and Cha, J.-H.* Molecular Characterization of Key Diphtheria Toxin:Receptor Interactions. Biochem. Biophys. Res. Commun. 275: 374–381 (2000).
 

9. Brooke, J.S., Cha, J.-H., and Eidels, L. Latent Transforming Growth Factor b-binding protein-3 and Fibulin-1c Interact with the Extracellular Domain of the Heparin-Binding EGF-like Growth Factor Precursor. BMC Cell Biology 3:2 (2002).
 

10. Cha, J.-H., Brooke, J.S., Chang, M.Y., and Eidels, L. A Receptor-Based Antidote For Diphtheria. Infection and Immunity 70:2344-2350 (2002).
 

11. Lee, J.-C., Cha, J.-H., Zerbv D.B., Stewart, G.C. Heterospecific Expression of the Bacillus subtilis Cell Shape Determination Genes mreBCD in Escherichia coli. Curr. Microbiol. 47:146-152 (2003).
 

12. Cha, J.-H.*, Chang, M.Y., and Eidels, L. Transgenic Mice Expressing the Diphtheria Toxin Receptor are Sensitive to the Toxin. Mol. Microbiol. 49:235-240 (2003).
 

13. Moon, S.-Y., Choi B.-K., Cha, J.-H.*., Min, C.-K., Son, M.-W., and Yoo, Y.-J. Inhibitory Effects of Artemisia asiatica on Osteoclast Formation Induced by Periodontopathogens. Food Sci. Biotechnol. 14:94-98 (2005).
 

14. Choi, B.-K., Moon, S.Y., Cha., J.-H*., Kim, K.W. and Yoo, Y.-J. Prostaglandin E2 is a main mediator in RANKL-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola and Treponema socranskii. J. of Periodontology 76:813-820 (2005)
 

15. Cho, I.-H, Jung, U.-W, Cha, J.-H*, Kim, J.-S, Lee, D.-S., Kim, C.-K. and Choi, S.-H. Clinical evaluation of full mouth disinfection therapy. The Journal of Korean Academy of Periodontology 35:597-608 (2005)
 

16. Nam, J.-A., Moon, S.-Y., Lee, J.-W., Cha, J.-H.*, Choi, B.-K. and Yoo Y.-J. Effect of Treponema lecithinolyticum lipopolysaccharide on matrix metalloproteinase-9 expression. The Journal of Korean Academy of Periodontology 35:675-686 (2005)
 

17. Yang, S.-E., Cha, J.-H.*, Kim E.-S., Kum, K.-Y., Lee, C.-Y., and Jung, I.-Y. Effect of smear layer and chlorhexidine treatment on the adhesion of Enterococcus faecalis to bovine dentin. Journal of Endodontics 32:663-667 (2006)
 

18. Choi, Ho Gil, Jin Moon Kim, Yun-Jung Yoo, and Jeong-Heon Cha*. Mouse Strain-Dependent Osteoclastogenesis in Response to Lipopolysaccharide. The Journal of Microbiology 45:566-571 (2007)
 

19. Shin, Su-Jung, Sang-Wook Jee, Song Jin-seon, Il-Yong Jung, Jeong-Heon Cha*, and Euiseong Kim. Comparison of regrowth of E. faecalis in dentinal tubules after sealing with gutta percha or Resilon. Journal of Endodontics 34:445-448 (2008)
 

20. Lee, Jeong Soon, Jae Myoung Suh, Yun-Jung Yoo, and Jeong-Heon Cha*. HB-EGF inhibits adipocyte differentiation at commitment and early induction stages. Differentiation 76:478-497 (2008)
 

21. Lee, Jeong Soon, Jin Moon Kim, Eun Kyoung Hong, Seong-Oh Kim, Yun-Jung Yoo, Jeong-Heon Cha*. Effect of HB-EGF on Wound Healing in Periodontal Ligament Cells. Journal of Periodontal Research. in press (2008)
 

22. Kim, So Yeong, Young Min Joo, Hak Sung Lee, In-Sik Chung, Yun Jung Yoo, Scott Merrell, and Jeong-Heon Cha*. Genetic Analysis of Helicobacter pylori Clinical Isolates Suggests Metronidazole Resistance Can Occur Without the Loss of Functional rdxA. J Antibiot (Tokyo). 62(1):43-50 (2009)

23. Jones K.R., Joo Y.M., Jang S., Yoo Y.J., Lee H.S., Chung I.S., Olsen C.H., Whitmire J.M., Merrell D.S., Cha J.H. Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. J Clin Microbiol. 47(4):959-68 (2009)