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Ganesh R.
Veerappan, MAJ, MC, USA
Assistant Professor of
Medicine, Dept. of Medicine, USUHS
Gastroenterology Service
Walter Reed
Army Medical Center
Washington, DC
Paper: "Prevalence of Eosinophilic
Esophagitis in an Adult Population Undergoing Upper Endoscopy: A Prospective
Study"
Authors:
Ganesh R. Veerappan, Joseph L. Perry, Timothy J. Duncan, Thomas P. Baker, Corinne
Maydonovitch, Jason M. Lake, Roy K.H. Wong, Eric M. Osgard
Clinical Gastroenterology and Hepatology Volume 7, Issue 4 , Pages 420-426.e2, April 2009
Background & Aims:
Eosinophilic esophagitis (EoE) is characterized by eosinophilic infiltration of
the esophagus. The purpose of this prospective study was to determine the
prevalence and clinical predictors of EoE in patients undergoing elective upper
endoscopy.
Methods: We enrolled 400 consecutive adults (median
age, 50 years; range, 19-92 years) who underwent routine upper endoscopy from
March to September 2007 at a tertiary care military hospital. All patients
completed a symptom questionnaire. All endoscopic findings were noted. Eight
biopsies were obtained from proximal and distal esophagus and were reviewed by
a blinded gastrointestinal pathologist. Patients had EoE if ≥20
eosinophils/high-power field were present.
Conclusions: The prevalence of EoE in an outpatient
population undergoing upper endoscopy was 6.5%. The characteristic findings of
EoE patients included male gender, history of asthma, and the presence of
classic findings of EoE on endoscopy, which is the strongest predictor of this
disease.
Amy C. Weintrob, MD
Assistant Professor of Medicine, Dept. of Medicine, USUHS
Infectious Disease Clinical Research Program
Walter Reed Army Medical Center
Washington, DC
Paper: "Host Determinants
of HIV-1 Control in African Americans"
Authors: Pelak
K, Goldstein DB, Walley NM, Fellay J, Ge D, Shianna KV, Gumbs C, Gao X, Maia JM,
Cronin KD, Hussain SK, Carrington M, Michael NL, Weintrob AC.
J Infect Dis 2010: 201 15 April
ABSTRACT: We performed a whole‐genome association study of human
immunodeficiency virus type
1 (HIV‐1) set point among a cohort of
African Americans (n=515), and
an intronic single‐nucleotide polymorphism (SNP) in the HLA‐B gene showed one of the strongest
associations. We use a subset of patients to demonstrate that this SNP reflects
the effect of the HLA‐B*5703 allele, which shows a genome‐wide statistically significant
association with viral load set
point. These analyses therefore confirm a member of the HLA‐B*57 group of alleles as the most important common
variant that influences viral load variation in African Americans, which is
consistent with what has been observed for individuals of European ancestry,
among whom the most important common variant is HLA‐B*5701
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