Pamnani, Motilal B., M.D., Ph.D., F.A.H.A
Professor of Anatomy, Physiology and Genetics
Professor of Medicine

Bombay University, 1956, 1963; Michigan State University,1974
 
Research Interests:
- Over the past 26 years this laboratory's research has been in the field of hypertension. In particular, the role of endogenous natriuretic factors in the mechanism of low renin, volume expanded type of hypertension. This type of hypertension is present in 30-40% of all essential hypertensives, especially in African American and the elderly. The research involves not only the understanding of the basic mechanism of this type of hypertension, but also its prevention and treatment. Therefore, several types of new antihypetnesive agents are under study to investigate their efficacy and the mechanism of action. Also, for the first time, a consistent experimental model of hypertension associated with diabetes mellitus (Type I), has been developed in this laboratory, to better understand the mechanism of this type of hypertension. More recently, in association with NASA, the role of endogenous natriuretic factors like sodium-potassium pump inhibitor and atrial natriuretic factor in the deconditioning of the cardiovascular system in simulated weightlessness is under investigation. Additionally, in collaboration with military investigators from WRAIR, the role of endothelium derived relaxing factor (EDRF). In particular, the role of two nitric oxide synthases (cNOS and iNOS) in hemorrhagic shock is being studied. Also recently, studies have begun to study the postponement of decompensation in hemorrhagic shock through extracellular potassium clamping by microdialysis and hemofiltration.
 
- MILITARY SIGNIFICANCE: Hemorrhagic shock is a dreaded complication of severe battlefield injuries. The present studies search for a therapy that will postpone decompensation and if necessary maintain tissue perfusion after the onset of the decompensation phase of hemorrhagic shock. This intervention could significantly improve the overall survival rates in the combat wounded.
 

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4301 Jones Bridge Road
Bethesda, Maryland 20814

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